Scarring Alopecia in a 66‐Year‐Old Woman

    February 2025 in “ JEADV Clinical Practice
    Sergio Castillo Pinto, Lina M. Isaza-Valencia, Isabel Cristina Cuellar Rios
    A 66-year-old woman presented with scarring alopecia and blistering on her scalp and periocular area, initially suspected to be herpes zoster or lichen planus pemphigoides. Histopathology and direct immunofluorescence confirmed a diagnosis of Brunsting-Perry Pemphigoid (BPP), a rare autoimmune blistering disease. BPP is characterized by subepidermal bullae and cicatricial alopecia, with antibodies targeting BP180 or BP230 antigens. Treatment with prednisolone and topical clobetasol, followed by methotrexate, led to complete healing. This case highlights the importance of considering BPP in cicatricial alopecia diagnoses and utilizing the salt-split test for diagnosis when serologic tests are unavailable. This is the third reported case of BPP in a Hispanic female.
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