does anyone else feel like the standard "big 3" just makes your hair look worse before anything good actually happens? Chat 4/14/2026
Using the "big three" hair loss treatments (Minoxidil, Finasteride, and Ketoconazole) can initially make hair look worse, often causing dryness and a "straw" texture. Adjusting the routine with gentler shampoos and conditioners can improve hair appearance while waiting for the treatments to show results.
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5 / 1000+ resultscommunity Big Three - 2 months in - trying to come back from the dead
User restarted hair loss treatment with consistent finasteride, minoxidil, ketoconazole shampoo, and weekly dermarolling. Another user shared their regimen including dutasteride, oral minoxidil, RU58841, derma roller, ketoconazole shampoo, and stemoxydine.
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This conversation is about a user, Jmilei, who has been using the "big three" hair loss treatments (Finasteride, Minoxidil, and Ketoconazole) for five years. After taking a two year break from treatment, they have recently restarted their regime and noticed results in the fourth month.
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community What happened to the big three? Ketoconazole is pretty magic for some and over the last few years it has been missing in people’s regiment quite a bit
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community Reddit’s amatorial meta analysis of 17 already avaliable hair loss prevention treatments that were found to be effective in clinical studies but are not FDA approved for MPB. PROS and CONS. (2022 Guide if Finasteride and Minoxidil are not working/ give you sides/are not enough) 77 studies linked!
The post and conversation are about hair loss treatments that have been found to be effective in studies. There are 19 different treatments mentioned, including oral minoxidil, oral dutasteride, topical finasteride, RU58841, and more. The best treatment for an individual depends on factors like availability, cost, side effects, and personal preferences.
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