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This study explored the efficacy and tolerance of a hair serum containing Silybum marianum extract, manganese PCA, and Lespedeza capitata extract in 30 men with androgenic alopecia following hair transplantation. Over 1 year, participants were divided into two groups: one using the serum with shampoo and the other using shampoo alone. Results indicated that the serum improved scalp tightness and discomfort shortly after use and enhanced hair condition and growth over time, with significant improvements noted from 1 to 12 months post-transplant. The serum was well-tolerated and accepted by patients, suggesting it as a beneficial dermocosmetic adjuvant for post-transplant hair care.

This study evaluated five isolation methods for human dermal papilla cells (hDPCs) to improve their clinical application in hair regeneration. The M5 method outperformed others by achieving high attachment efficiency, reduced processing time, and enhanced proliferative capacity while maintaining key hair-inductive markers and activating important signaling pathways. M5-derived hDPCs effectively induced hair growth in vivo, showing physiological responsiveness similar to treatments with minoxidil and dihydrotestosterone. The M5 method offers a robust platform for scalable hDPC isolation, preserving their biological potency for regenerative applications in alopecia.

The study formulated and evaluated a polyherbal Ayurvedic hair regrowth oil containing extracts of Bhringraj, Amla, Brahmi, Hibiscus, and Fenugreek. Three formulations were tested, with F2 showing optimal characteristics, including a pH of 6.6 and viscosity of 1280 cP. Hair growth studies on albino rats indicated significant enhancement in hair growth initiation and length compared to the control group, with results comparable to standard treatments. The effectiveness is attributed to the synergistic effects of phytoconstituents like flavonoids and antioxidants. The study suggests the oil is a promising natural solution for hair growth and scalp health, recommending further clinical trials for human efficacy and safety.

The study formulated and evaluated a polyherbal Ayurvedic hair regrowth oil containing extracts of Bhringraj, Amla, Brahmi, Hibiscus, and Fenugreek. Three formulations were tested, with F2 showing optimal characteristics, including a pH of 6.6 and viscosity of 1280 cP. Hair growth studies on albino rats indicated significant enhancement in hair growth initiation and length compared to the control group, with results comparable to standard treatments. The effectiveness is attributed to the synergistic effects of phytoconstituents like flavonoids and antioxidants. The study suggests the formulation is promising for promoting hair growth and reducing hair fall, recommending further clinical trials for human efficacy and safety.

The study formulated and evaluated a polyherbal Ayurvedic hair regrowth oil containing extracts of Bhringraj, Amla, Brahmi, Hibiscus, and Fenugreek. Three formulations were tested, with F2 showing optimal characteristics, including a pH of 6.6 and viscosity of 1280 cP. Hair growth studies on albino rats indicated significant hair growth enhancement compared to the control group, with results comparable to standard treatments. The effectiveness is attributed to the synergistic effects of the phytoconstituents in the plants. The study concludes that the polyherbal oil is a promising natural formulation for promoting hair growth and recommends further clinical trials in humans.

The study formulated and evaluated a polyherbal Ayurvedic hair regrowth oil containing extracts of Bhringraj, Amla, Brahmi, Hibiscus, and Fenugreek. Three formulations were tested, with F2 showing optimal characteristics, including a pH of 6.6 and viscosity of 1280 cP. Hair growth studies on albino rats indicated significant hair growth enhancement compared to the control group, with results comparable to standard treatments. The effectiveness is attributed to the synergistic effects of the phytoconstituents in the plants. The study concludes that the polyherbal oil is a promising natural formulation for promoting hair growth and recommends further clinical trials in humans.

The study formulated and evaluated a polyherbal hair oil using natural ingredients like Amla, Fenugreek, and Coconut oil, among others. Three formulations were tested, with F2 showing superior physicochemical properties, including acceptable pH, moderate viscosity, pleasant odor, and good stability. F2 also demonstrated anti-dandruff, anti-hair fall, antimicrobial, conditioning, and hair growth-promoting activities, making it the optimized and stable formulation for herbal hair care applications.

The study formulated and evaluated a polyherbal hair oil using natural ingredients like Amla, Fenugreek, and Coconut oil, among others. Three formulations (F1, F2, F3) were tested for various properties. Formulation F2 emerged as the most effective, showing optimal physicochemical properties, stability, and biological activities, including anti-dandruff, anti-hair fall, antimicrobial, conditioning, and hair growth-promoting effects. F2 was deemed the best formulation for herbal hair care applications.

This study focuses on the formulation and characterization of a herbal-based antidandruff shampoo using traditional herbs like neem, fenugreek seed, aloe vera, and clove, known for their therapeutic and antimicrobial properties. The shampoo's effectiveness was evaluated through phytochemical screenings and Fourier transform infrared spectroscopy (FTIR), confirming the presence of bioactive compounds. Two shampoo formulations were tested for antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis, and antifungal activity against Malassezia furfur, using the agar well diffusion method. The study analyzed parameters such as pH, foaming agents, solid content, and organoleptic properties to ensure stability and user acceptance. The findings suggest that the herbal antidandruff shampoo is a promising natural alternative for addressing dandruff and improving scalp health.

This study focuses on the formulation and characterization of a herbal-based antidandruff shampoo using traditional herbs like neem, fenugreek seed, aloe vera, and clove, known for their therapeutic and antimicrobial properties. The shampoo's effectiveness was evaluated through phytochemical screenings and Fourier transform infrared spectroscopy (FTIR), confirming the presence of bioactive compounds. Two shampoo formulations were tested for antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis, and antifungal activity against Malassezia furfur, a fungus linked to dandruff. The study's findings highlight the shampoo's stability, quality, and potential therapeutic benefits, offering a promising natural alternative for dandruff treatment.

This case report discusses a rare instance of pressure alopecia in a four-year-old patient who developed an alopecic patch after a two-week stay in the intensive care unit. Despite early treatment with steroids and zinc pyrithione shampoo, the patient showed signs of scarring alopecia. Trichoscopy, which revealed comedone-like dots, was crucial in diagnosing this condition. The report highlights the importance of early detection and a high index of suspicion for pressure alopecia in pediatric patients with prolonged immobilization, as early intervention is key to preventing permanent hair loss.

The study investigated the impact of a modified diet on skin changes in a rat model of stress-induced alopecia. Female Wistar rats were used to model stress alopecia, and a diet rich in natural antioxidants and nutrients was tested for its corrective effects. Rats on the modified diet showed significantly better skin conditions, with less epidermal atrophy and healthier hair follicles compared to those without dietary changes. The modified diet helped preserve the functional activity of hair follicles and reduced dystrophic changes in the skin, suggesting that dietary approaches can be effective in managing stress-induced alopecia.

Cutaneous fibrosis is characterized by abnormal tissue remodeling due to chronic inflammation, tissue trauma, or autoimmune reactions, leading to decreased tissue function and reduced quality of life. The epithelial–mesenchymal transition (EMT) is identified as a critical factor in the development of fibrotic disorders, although its exact contribution compared to other cell sources is not fully understood. Recent findings highlight EMT's role in fibrogenesis and suggest new molecular targets for therapy. This review aims to enhance understanding of EMT's regulatory mechanisms in cutaneous fibrosis and explore potential treatment strategies.

This study investigates potential multi-target drugs against Onchocerca volvulus, a major cause of blindness in developing regions. Using molecular docking simulations, 2,015 approved drugs were screened against glutamate S-transferase and prolyl tRNA synthetase. Bedaquiline and Telmisartan showed the strongest binding affinities, while Diosmin, Azelastine, and Adapalene were identified as promising multi-target drugs based on molecular dynamics. Other compounds like Drospirenone, Alectinib, Dutasteride, and Finasteride also showed potential. The study suggests repurposing these drugs could offer effective treatments for onchocerciasis, with further validation needed.

This review discusses the advancement of hair follicle organoids towards immune-competent hair follicle microphysiological systems (HF-MPS), which aim to better replicate the immune, vascular, neural, and dynamic regulatory features of native hair follicles. These systems are particularly important for studying immune-mediated hair disorders like alopecia areata, where immune privilege collapse and inflammatory infiltration are key issues. The review outlines the structural basis of HF engineering and defines immune competence as maintaining immune privilege, regulating hair follicle cycling and regeneration, and managing inflammatory injury. It also explores engineering strategies such as local immune microenvironment control and dynamic perfusion. The applications of HF-MPS in disease modeling, drug evaluation, and regenerative medicine are discussed, emphasizing that these systems are evolving platforms rather than complete replacements for existing models.

The study focuses on developing a nanosponge-based aloe vera gel incorporating Epigallocatechin gallate (EGCG) and fenugreek seed extract (FSE) to treat Alopecia Areata. EGCG, a potent antioxidant from green tea, faces challenges like poor stability and permeability, while fenugreek seeds are known to promote hair growth by affecting dihydrotestosterone synthesis. Aloe vera is recognized for its nourishing properties that support hair health. The research aimed to enhance the delivery and efficacy of these compounds using a nanosponge system, which offers controlled drug release, stability, and improved cellular uptake. Ethyl cellulose and polyvinyl alcohol were used in the synthesis, and the formulation was optimized for particle size, encapsulation efficiency, and drug release.

The document reviews the principles of hair dye, categorizing them into oxidative and non-oxidative dyes, with non-oxidative dyes further divided into temporary and semi-permanent types. By analyzing these principles, the study aims to improve the quality and safety of hair dyes, making the dyeing process safer and more convenient. The review highlights significant differences in the duration, application methods, and potential risks associated with each type of dye, suggesting that understanding these differences can lead to better and safer hair dye products.

This study introduces a natural hair-coloring system using size-controlled ink particles (SIPs) from cuttlefish ink and chitosan, addressing concerns about conventional dyes. The SIPs, initially negatively charged, were modified through polyelectrolyte complexation with chitosan to reverse their charge under acidic conditions, allowing effective electrostatic deposition onto hair fibers. The optimal SIP:chitosan weight ratio of 10:1 at pH ~4.7 produced the darkest and most uniform black coloration without using metallic mordants, surpassing the performance of plant-based natural colorants. This marine-biomass-derived method offers a promising alternative for safe and effective hair dyeing.

This review explores herbal approaches for managing premature hair greying (PHG), focusing on mechanisms, phytoconstituents, and delivery strategies. It highlights the limitations of synthetic dyes and emphasizes the potential of herbal remedies to maintain follicular melanin, enhance antioxidant defenses, and improve melanogenic pathways. Ethnopharmacological leads from Ayurveda, Traditional Chinese Medicine, Japanese Kampo, and Unani medicine include Eclipta alba, Emblica officinalis, and others, with phytoconstituents like gallic acid and wedelolactone. Advanced delivery systems such as ethosomes and nanostructured lipid carriers may enhance treatment efficacy. However, the review stresses the need for botanical authenticity, standardization, toxicological profiling, and controlled trials to validate these treatments, suggesting they remain evidence-developing until further human research is conducted.

In the first 10 months following its FDA approval in June 2023, ritlecitinib was prescribed to a diverse group of patients aged ≥12 years with severe alopecia areata (AA) in the USA. This study analyzed data from 2,562 patients in cohort 1 and 381 in cohort 2, revealing that 62% were prescribed ritlecitinib by dermatologists, 59% were female, and 35% were adolescents. Approximately 24% had severe AA forms like alopecia totalis or universalis, 12% had other autoimmune disorders, 24% had atopic disorders, and 24% had mental health conditions. Before starting ritlecitinib, 27% had no prior AA treatments, while about one-third received systemic immunomodulators or injectable corticosteroids. In cohort 2, 77% experienced ≥50% scalp hair loss. The findings suggest ritlecitinib offers new opportunities for engaging patients in AA care, regardless of their treatment history or comorbidities.

The study investigates a polyherbal hair growth oil formulated with botanical substances like Bhringraj, Hibiscus Rosa Sinensis, Rosemary, Brahmi, and Vetiveria Zizanioides, using coconut, castor, and black seed oils as bases. The oil was prepared using an infusion technique and tested for physical properties, safety, and sensory characteristics. Results show that the oil is stable, non-irritating, and safe for external use. The herbal compounds exhibit synergistic effects that may promote hair growth through mechanisms such as follicle nourishment, improved scalp blood flow, and antioxidant and anti-inflammatory properties. The research suggests that natural herbal treatments could be a sustainable and effective alternative to artificial hair treatments.

This study developed a natural, herbal-based powder for facial hair removal, incorporating ingredients like turmeric, rice flour, and sandalwood powder, known for their skin benefits. The formulation was adjusted for effectiveness and safety, and evaluated for physical properties and user satisfaction. Results indicated the product was successful and holds promise as a skincare solution.

The study focused on creating and evaluating a herbal shampoo using rice water and willow bark extract as natural alternatives to synthetic ingredients. Rice water was chosen for its hair-conditioning and strengthening benefits, while willow bark extract was included for its gentle keratolytic and scalp-soothing properties. The shampoo was tested for various attributes such as physical appearance, pH, viscosity, foamability, spreadability, stability, and antimicrobial potential. The results indicate that the combination of rice water and willow bark extract can effectively cleanse, nourish, protect the scalp, and improve hair manageability without the harsh effects of chemicals, supporting healthy hair and scalp care.

The study focused on creating and evaluating a herbal shampoo using rice water and willow bark extract as natural alternatives to synthetic ingredients. Rice water was chosen for its hair-conditioning and strengthening benefits, while willow bark extract was included for its gentle exfoliating and soothing effects on the scalp. The shampoo was tested for various properties, including appearance, pH, viscosity, foamability, spreadability, stability, and antimicrobial potential. The results indicate that the combination of rice water and willow bark extract effectively supports healthy hair and scalp care, offering cleansing, nourishment, and protection without the harsh effects of chemicals.

The study on canine demodicosis, conducted at the Veterinary Clinical Complex in Bikaner, Rajasthan, examined 240 dermatitis cases in dogs, identifying 25 positive cases of demodicosis through deep skin scrapings. Among these, 19 dogs had generalized demodicosis, while 6 had localized demodicosis. Hematological analysis revealed anemia, leucocytosis, neutrophilia, lymphopenia, and eosinophilia, while serum biochemistry showed hypoglycemia, hypoproteinemia, hypoalbuminemia, hyperglobulinemia, and elevated SGPT and SGOT levels. Mineral analysis indicated decreased serum zinc, copper, and iron levels. Histopathological findings included desquamation, degeneration of external root sheath cells, necrotic hair follicles filled with keratin and debris, and cross-sections of mites in the epidermis with hyperpigmentation.

Glucagon-like peptide 1 receptor agonists (GLP-1RAs), used for type 2 diabetes and weight loss, have been linked to hair loss, particularly with semaglutide and tirzepatide, though causality is not established. Evidence primarily comes from pharmacovigilance databases and retrospective studies, with no prospective, controlled studies specifically addressing this issue. Rapid weight loss from these drugs may cause telogen effluvium, a potential mechanism for hair loss. As prescriptions rise in Europe, cases may increase, necessitating further research into causality and risk factors. Clinicians should inform and monitor patients for potential hair loss.