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    Dutasteride Dosage Simulator

    Pharmacokinetic & pharmacodynamic simulation based on the Gisleskog et al. model. Visualizes serum dutasteride concentration and DHT suppression for custom dosing schedules.

    Disclaimer: This simulation models population averages based on published pharmacokinetic parameters. Individual responses vary significantly due to genetics, body composition, and other factors. This tool is for educational purposes only and should not be used to make medical decisions or adjust dosing. Always consult a qualified healthcare provider. Model implementation adapted from FuzzyCat444's open-source work.
    References
    1. Gisleskog PO, Hermann D, Hammarlund-Udenaes M, Karlsson MO. The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination. Br J Clin Pharmacol. 2001. doi:10.1046/j.1365-2125.1999.00843.x
    2. Gisleskog PO, Hermann D, Hammarlund-Udenaes M, Karlsson MO. A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride. Clin Pharmacol Ther. 1998. doi:10.1016/S0009-9236(98)90054-6
    3. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride. J Am Acad Dermatol. 2006. doi:10.1016/j.jaad.2006.05.007