0877 Activated wound phenotype and microbial dysbiosis are driven by AhR suppression in hidradenitis suppurativa tunnels

    July 2025 in “ Journal of Investigative Dermatology ”
    Raji R. Nagalla, N. Balukoff, Jelena Marjanović, Ali Kamiar, Andrew P. Sawaya, E. Zhivov, Barry I. Resnik, Hadar Lev‐Tov, Marjana Tomic‐Canic, I. Pastar
    TLDR Reduced AhR signaling in HS tunnels leads to persistent inflammation and microbial imbalance.
    This study investigates the role of the aryl hydrocarbon receptor (AhR) pathway in the pathogenesis of hidradenitis suppurativa (HS) tunnels, focusing on tissue repair dysregulation and microbial imbalance. Using gene ontology and pathway analysis, along with RNA sequencing and microbiome profiling, the researchers found that HS tunnel tissues exhibit an activated wound phenotype, characterized by unique expression of keratin 17 and faster keratinocyte migration. This phenotype is linked to decreased AhR signaling and reduced levels of commensal bacteria like Cutibacterium and Lactobacillus. The study suggests that the suppression of AhR signaling contributes to the persistent inflammation and dysbiosis observed in HS tunnels, providing a potential target for therapeutic intervention.
    Discuss this study in the Community →

    Related Community Posts Join

    4 / 4 results

      community PP405 bandwagon, time to resume the hype train.

      in Treatment  164 upvotes 6 months ago
      PP405 shows promise in hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil, with significant results in just four weeks. The treatment is still in early stages, with further trials needed to determine its long-term effectiveness and optimal dosage.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 6 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community PP405 is out for sale on everychem.

      in Product  100 upvotes 7 months ago
      PP405 is suspected to be a scam, with users doubting its legitimacy and effectiveness. Many recommend using proven treatments like finasteride and minoxidil.

      community Getting PP405. Now…. or as soon as possible

      in Research/Science  146 upvotes 8 months ago
      People are discussing obtaining and testing PP405 for hair loss treatment, with concerns about its purity and effectiveness. Some are considering delaying hair transplants, while others suggest using existing treatments like finasteride and minoxidil.

    Similar Research

    5 / 347 results