Gamma Delta 17 T Cell-Stromal Networks Modulate Matrix Composition and Vascularity in Foreign Body Response

This study explores the role of γδ T cells in modulating tissue fibrosis during the foreign body response, focusing on their interaction with stromal cells. The research highlights that γδ17 T cells, which produce interleukin-17, persist as fibrosis progresses and are influenced by aging and a high-fat diet. These cells stimulate fibroblasts to express collagen genes and activate ECM remodeling and vascular development in fibroblasts and endothelial cells. Genetic deletion of γδ T cells resulted in altered ECM component expression and increased vessel size in the fibrotic matrix, suggesting that γδ T cells play a crucial role in regulating stromal behavior and the composition and vascularity of fibrotic tissues.