3D Bioprinted GelMA Scaffolds Loaded with Runx2 Overexpressed BMSCs for Bone Regeneration

    August 2026 in “ Materials & Design ”
    Jinhao Huang, Wenfeng Li, Zongqin Tang, Yiyang Su, Xiang He, Jiamian Zhou, Wei Chen, Fanrong Ai, Qingming Shi
    TLDR 3D bioprinted scaffolds with modified stem cells improve bone healing.
    The study explores a novel approach to bone regeneration by using 3D bioprinted methacrylated gelatin (GelMA) scaffolds loaded with Runx2-overexpressing bone marrow mesenchymal stem cells (Runx2-OE-BMSCs). The Runx2 gene, a key osteogenic transcription factor, was introduced into BMSCs using lentiviral vectors to enhance their osteogenic differentiation capacity. The resulting Runx2-OE-BMSCs@GelMA scaffolds demonstrated excellent biocompatibility and significantly improved osteogenic differentiation in vitro. In vivo experiments further confirmed their effectiveness in enhancing bone regeneration. This strategy provides new insights into treating bone defect-related diseases by focusing on enhancing osteoblast activity.
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