Three-Dimensional Bioprinting Techniques in Skin Regeneration: Current Insights and Future Perspectives

Recent advancements in 3D bioprinting technologies have shown promise in skin regeneration by enabling the creation of structures that closely mimic native tissues. This approach addresses the limitations of traditional skin transplantation, such as hemostasis, donor area closure, graft contraction, and scarring. Bioprinting offers advantages like high reproducibility, precision, and the ability to create complex geometries. The review emphasizes innovative studies on 3D-printed bioinks, particularly those involving exosome-loaded bioinks, which show potential in supporting skin regeneration and repair due to their excellent biocompatibility, biodegradability, and mechanical stability.