Poor Capability of 3D-Cultured Adipose-Derived Stem Cells to Induce Hair Follicles in Contrast to 3D-Cultured Dermal Papilla Cells

January 2016 in “ Annals of Dermatology ”

Chang Hoon Seo, Mi Hee Kwack, Soo‐Hong Lee, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung

3D-cultured dermal papilla cells adipose-derived stem cells hair follicles trichogenic markers versican Sox2 hair-inductive interactions hair regeneration therapies

TLDR 3D-cultured dermal papilla cells are better at inducing hair follicles than adipose-derived stem cells.

The study found that 3D-cultured dermal papilla (DP) cells had a significantly higher capability to induce hair follicles compared to adipose-derived stem cells (ADSCs). While DP spheres consistently induced hair follicle formation when combined with mouse epidermal cells, ADSC spheres induced very few hair follicles. The expression of trichogenic markers such as versican and Sox2 was higher in DP spheres, indicating their importance in hair-inductive interactions. The study concluded that ADSCs were not a promising substitute for trichogenic DP cells in hair follicle induction, highlighting the potential of DP cells in hair regeneration therapies.

View this study on anndermatol.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Defining Dermal Adipose Tissue

218 citations , May 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

Two fibroblast types shape skin structure and repair differently.

research Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering

57 citations , February 2013 in “Journal of Dermatological Science”

Improving the environment and cell interactions is key for creating human hair in the lab.

Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay

research Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay

75 citations , August 2011 in “Journal of Investigative Dermatology”

Forming spheres boosts the ability of certain human cells to create hair follicles when mixed with mouse skin cells.

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

131 citations , July 2009 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Related Community Posts Join

6 / 42 results

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 2 years ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Developing a Cheap Low-Level Laser Therapy Device for Hair Loss

in Technology 6 upvotes 3 years ago

Low-level laser therapy (LLLT) stimulates hair growth but current devices are expensive. A proposed non-profit project aims to create affordable, 3D-printed LLLT devices and collect data on their effectiveness.

community Am I taking out too much foam for a dose? Rogaine Minoxidil

in Minoxidil 2 years ago

This conversation discusses the topical application of Minoxidil, with various users providing advice on how to accurately measure a dose and keep it from melting too quickly. Others have shared their experiences using oral finasteride for hair loss treatments.

community Scalp Micropigmentation while having hair

in Treatment 6 upvotes 3 years ago

User discusses scalp micropigmentation for denser hair appearance and its benefits compared to lifelong treatments. Special ink is used, which can fade and blur over time but can be topped up.

community May to today (dut 0.5mg everyday 3.5 months). Is it normal for my sensitive areas to miniaturize crazy?

in General 81 upvotes 3 months ago

The user is experiencing increased hair miniaturization despite using oral minoxidil, dutasteride, and microneedling. They are considering reintroducing finasteride and adjusting dutasteride dosage.

Related Research

7 / 7 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations , April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Characterization of Hair Follicle Development in Engineered Skin Substitutes

41 citations , June 2013 in “PLOS ONE”

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.