3D-Printed Hydrating Masque for Diabetic Wound Repair: A Nitric Oxide-Enhanced Tremella Polysaccharide-Based Scaffold for Improved Wound Comprehensive Regulation

January 2026 in “ Advanced Healthcare Materials ”

Jiabao Xu, Yang Wang, Jingjing Cao, Kun Xia, Chaoyang Zong, Cong Ye, Baisheng Cai, Su Jiang, Wei Ji, Hongdong Ma, Fei Han, Ran Tao, Caichou Zhao, Yue Lu

tremella polysaccharides nitric oxide gallium ions angiogenesis hair follicle regeneration aquaporin re-epithelialization

TLDR A 3D-printed masque helps diabetic wounds heal faster by reducing inflammation and promoting skin regeneration.

The study introduces a 3D-printed scaffold, LZ@TMG, designed for diabetic wound repair, utilizing the moisturizing properties of tremella polysaccharides (TP) combined with nitric oxide (NO) nanoreactors and gallium ions. This scaffold effectively releases NO and Ga 3+ to inhibit bacterial growth and modulates oxidative stress and inflammation, promoting angiogenesis during wound healing. In a mouse model, LZ@TMG reduced inflammation, promoted blood vessel and hair follicle regeneration, and accelerated wound healing. It also enhanced aquaporin expression, improved skin hydration, and expedited re-epithelialization, offering a promising strategy for moist wound healing in diabetes.

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