682 Identification of novel potential therapeutic targets by comparative transcriptomic profiling of physiological and pathological skin wounds ex vivo

    July 2024 in “ Journal of Investigative Dermatology ”
    Ilaria Piccini, Markus Fehrholz, R.J. Ludwig, J. Ziber, Jan Alenfall, Anders Nilsson, Jan Nilsson, Ralf Paus, Marta Bertolini
    TLDR Combining certain treatments, including FOL005, may improve healing of difficult wounds.
    This study investigates the molecular mechanisms of wound healing by comparing transcriptomic profiles of acute and chronic wounds in cultured human skin. Key findings include differential expression of genes like FGF7, MMP10, and osteopontin (SPP1) between acute and chronic wounds. Notably, MMP10-neutralizing antibody increased wound healing in acute wounds, while recombinant FGF7 alone had no effect. However, their combined application enhanced re-epithelization in both wound types. Additionally, the osteopontin-derived peptide FOL005 significantly promoted skin re-epithelization under both conditions. The study suggests that combined therapeutic targeting, including the use of FOL005, may improve treatment of unresolved wounds.
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