85 Primary Cutaneous Follicle Center Lymphoma Spans Yet Unrecognized Subtypes Including Polyclonal Reactions

    November 2025 in “ Journal of Investigative Dermatology ”
    Iñigo Oyarzun, S. Gansberger, Martín Simón, Sofia Santos, Patrick M. Brunner, Constanze Jonak, Johannes Griss
    TLDR PCFCL may have unrecognized subtypes and needs more research.
    The study investigates primary cutaneous follicle center lymphoma (PCFCL), a subtype of primary cutaneous B-cell lymphomas, using single-cell RNA sequencing and B-cell receptor sequencing on samples from 11 patients. The results reveal unexpected heterogeneity within PCFCL, particularly regarding clonal expansion, as only 5 samples showed a clearly expanded B-cell clone composed exclusively of germinal center B cells. This finding challenges current understanding, suggesting that PCFCL may include distinct, yet unrecognized, subtypes, indicating that it is a poorly understood disease requiring further research.
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