A dual-mechanism injectable hydrogel integrating reactive oxygen species regulationand low-level laser therapy for androgenetic alopecia remediation

The study presents a novel multifunctional hydrogel system designed to treat androgenetic alopecia (AGA) by addressing both reactive oxygen species (ROS) accumulation and insufficient microcirculation, which are key factors in AGA progression. This hydrogel integrates multi-active nanozymes and melanin nano photothermal agents, allowing for precise and sustained release of nanodrugs. The nanozymes mimic superoxide dismutase and catalase activities to clear ROS, restoring redox balance in hair follicles. Concurrently, the melanin agents, activated by infrared laser, stimulate hair follicle cells and enhance microcirculation. This dual-mechanism approach offers a promising multi-target precision therapy for improving the follicular microenvironment and promoting healthy hair growth in AGA patients.