A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence

The study presents a near-infrared (NIR)-responsive polydopamine-resveratrol (PDA@RES) core-shell nanoplatform designed to enhance chronic wound healing by addressing inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. This nanoplatform combines photothermal therapy and drug delivery, showing strong antioxidant and anti-inflammatory effects by reducing reactive oxygen species, restoring mitochondrial function, and promoting a pro-healing macrophage phenotype. It activates the AMPK/PGC-1α signaling pathway, enhancing mitophagy and mitochondrial biogenesis, which reverses cellular senescence. In diabetic rat models, the treatment accelerated wound healing, improved collagen deposition, balanced the immune environment, and supported vascular regeneration, notably inducing new hair follicle structures for regenerative healing. This approach offers a promising multi-target therapeutic strategy for chronic wound management.