A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

This study assessed the effects of a polyphenol-rich fruit extract combined with biotin on skin and hair health in 54 women, with 52 completing the trial. Over 12 weeks, the supplement group experienced significant reductions in hair shedding, with decreases of 30.90% at 28 days and 41.58% at 56 days compared to the placebo group. While improvements in wrinkle morphology and skin surface roughness were observed, they were not statistically significant. The findings suggest potential benefits of the supplement for reducing hair shedding, but the limited statistical significance in some outcomes suggests cautious interpretation, and larger trials are needed to confirm these results.