A Systematic Review on the Treatment of Pediatric Severe Alopecia Areata by Topical Immunotherapy, Anthralin, or Low-Level Light/Laser Therapy: Focus on Efficacy, Safety, Treatment Duration, Recurrence, and Follow-Up Based on Clinical Studies

October 2021 in “ Journal of Cosmetic Dermatology ”

Elham Behrangi, Masoumeh Roohaninasab, Afsaneh Sadeghzadeh‐Bazargan, Niloufar Najar Nobari, Mohammadreza Ghassemi, Farnoosh Seirafianpour, Azadeh Goodarzi, Milad Dodangeh

alopecia areata topical immunotherapy Anthralin contact sensitization low-level light therapy low-level laser therapy LLLT alopecia light therapy laser therapy

TLDR All three treatments help manage alopecia areata in children, but more research is needed for long-term effects.

The systematic review focused on evaluating the efficacy, safety, treatment duration, recurrence, and follow-up of pediatric severe alopecia areata treatments, specifically topical immunotherapy, Anthralin (contact sensitization), and low-level light/laser therapy (LLLT). The review analyzed clinical studies to determine the effectiveness of these treatments in children. It concluded that while all three treatments showed some level of efficacy in managing alopecia areata, there were variations in treatment duration and recurrence rates. Safety profiles were generally acceptable, but the review highlighted the need for more extensive studies to better understand long-term outcomes and optimize treatment protocols for pediatric patients.

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research A Systematic Review of the Effect of Platelet-Rich Plasma on Androgenetic Alopecia in Women

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research Photobiomodulation for the Management of Alopecia: Mechanisms of Action, Patient Selection, and Perspectives

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research Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata

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research Topical 2% Tofacitinib for Children with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis

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research Alopecia Areata: Treatment Options and Efficacy

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research Alopecia Areata: A Comprehensive Review of Pathogenesis and Management

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research Higher Concentrations of Dithranol Appear to Induce Hair Growth Even in Severe Alopecia Areata

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research Bilateral Half-Head Comparison of 1% Anthralin Ointment in Children with Alopecia Areata

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research A Systematic Review of Pulse Steroid Therapy for Alopecia Areata

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Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial

research Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial

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research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

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research Effectiveness of 308-nm Excimer Laser Therapy in Treating Alopecia Areata by Examining Treated Sides of Selected Alopecic Patches

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research Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children

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research The Safety and Efficacy of Diphencyprone for the Treatment of Alopecia Areata in Children

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research Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata

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research Alopecia Areata Update

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research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

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research Alopecia Areata: Review and Update

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research Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

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research Chronic Delayed-Type Hypersensitivity Reaction as a Means to Treat Alopecia Areata

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