Alopecia Areata and Systemic Lupus Erythematosus: Insights From a Nationwide Case-Control Study

    May 2025 in “ International Journal of Dermatology ”
    Yonit Wohl, A. Maruani, Amir Ben‐Tov, Yarden Drutin, Jacob Mashiah
    TLDR Alopecia areata patients are more likely to develop systemic lupus erythematosus.
    This nationwide case-control study investigated the prevalence of systemic lupus erythematosus (SLE) in patients with alopecia areata (AA) using data from 33,401 AA patients and 66,802 matched controls. The study found a significant association between AA and SLE, with an odds ratio of 3.63, indicating that AA patients are more likely to develop SLE compared to controls. This association was consistent across all age groups, with the strongest link observed in children. The study highlights the importance of screening and monitoring AA patients for SLE, as well as considering early targeted treatments like Janus kinase inhibitors, which are being explored for both conditions. Despite its strengths, the study was limited by the lack of data on AA severity and specific SLE subtypes.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

      in Treatment  8 upvotes 5 years ago
      Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

      in Chat  15 upvotes 1 year ago
      A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

      community Hairloss all over body and head

      in Treatment  2 upvotes 1 month ago
      A 25-year-old experiencing hair thinning all over the body and head, despite using minoxidil and having low vitamin D levels, is advised to seek a second opinion from a dermatologist specializing in hair loss. The likely diagnosis is diffuse alopecia areata, which may require treatment with a JAK inhibitor.

    Related Research

    2 / 2 results