Alkaline Ceramidase 1 Is Essential for Mammalian Skin Homeostasis and Regulating Whole-Body Energy Expenditure

    April 2016 in “ The Journal of Pathology ”
    Kifayathullah Liakath‐Ali, Valerie E. Vancollie, Christopher J. Lelliott, Anneliese O. Speak, David Lafont, Hayley Protheroe, Camilla Ingvorsen, Antonella Galli, Angela Green, Diane Gleeson, Edward J. Ryder, Leanne Glover, Gema Vizcay‐Barrena, Natasha A. Karp, Mark J. Arends, Thomas Brenn, Sarah Spiegel, David J. Adams, Fiona M. Watt, Louise van der Weyden
    TLDR Alkaline ceramidase 1 is crucial for healthy skin and energy balance.
    The study found that alkaline ceramidase 1 (Acer1) was essential for skin homeostasis and energy regulation in mice. Acer1-deficient mice showed increased ceramide levels, leading to abnormal hair follicle formation, cyclic alopecia, and epidermal hyperplasia. These mice experienced increased transepidermal water loss and hypermetabolism, resulting in reduced fat content and lower body weights. Despite these issues, the mice were viable and fertile. The study highlighted Acer1's role in ceramide metabolism, crucial for epidermal differentiation, hair function, and maintaining energy balance.
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