Acetaminophen-Induced Infertility in Male Wistar Rats: Impact of Avocado Leaves on Hormonal Profile and Semen Analysis

November 2024 in “ Asian Journal of Biological Sciences ”

Usiobeigbe Osahon Stanley, Iyevhobu Kenneth Oshiokhayamhe, Obohwemu Kennedy Oberhiri, Omolumen Lucky Eromosele, Airhomwanbor Kingsley Osayande, A. Gould Ernest, Irobonosen Israel Osaze, Moses Mukosha, Ann Bonner Anthony, Ikede Rex Ehizojie, Othieno Emmanuel, Omoregie Jesse, Lagundoye Sherifat Bolade, Adelani Aderonke Abimbola

acetaminophen avocado leaves LH FSH testosterone semen analysis sperm motility sperm viability paracetamol

TLDR High consumption of avocado leaves harms male fertility.

The study investigated the effects of acetaminophen and avocado leaves on the hormonal profile and semen analysis in 42 male Wistar rats. Acetaminophen administration increased LH and FSH hormones, with excessive FSH potentially affecting reproduction negatively. Testosterone levels increased at lower doses but decreased at higher doses of acetaminophen. Avocado leaf extract significantly reduced body weight and negatively impacted semen, sperm motility, and viability, suggesting that high consumption of avocado leaves adversely affects the male reproductive system.

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Acetaminophen-Induced Infertility in Male Wistar Rats: Impact of Avocado Leaves on Hormonal Profile and Semen Analysis

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