Acute Granulomatous Interstitial Nephritis Post-COVID-19 Vaccination

This document presents a case study of a 56-year-old Caucasian male who developed acute granulomatous interstitial nephritis likely associated with the Moderna COVID-19 vaccine. The patient, with a history of dyslipidemia, erectile dysfunction, and alopecia, experienced a significant decline in kidney function three months post-vaccination, with eGFR dropping from 70 cc/min to 8 cc/min. A renal biopsy confirmed the condition, and treatment with high-dose prednisone improved his eGFR to 40 cc/min. However, upon stopping prednisone, his eGFR declined again, and a third biopsy showed recurrence of granulomas. The patient responded to prednisone and was maintained on Cellcept, which stabilized his eGFR at 38 cc/min. The study suggests a potential link between the vaccine and the condition, with a positive response to steroid treatment followed by Cellcept.