Cell-Free Adipose Extract Inhibits Hypertrophic Scar Formation Through Collagen Remodeling and Antiangiogenesis

January 2025 in “ Open Medicine ”

Jianghua Sun, Yujie Zhao, Zhican Qu, Shudong Sun, Kun Wang

cell-free adipose extract collagen remodeling antiangiogenesis hypertrophic scar collagen deposition scar tissue scar proliferation

TLDR High-concentration cell-free adipose extract reduces scar formation and improves scar appearance.

The study investigates the effects of cell-free adipose extract (CEFAE) on hypertrophic scar formation using a rabbit ear scar model. The research compared a control group with low and high concentrations of CEFAE. Results showed that the high-concentration CEFAE group had the best outcomes, with reduced collagen deposition, thinner skin layers, and more organized collagen structure. Additionally, there was a significant reduction in new blood vessel formation, which helps suppress scar tissue development. These findings suggest that high-concentration CEFAE effectively prevents and treats scar proliferation, offering new therapeutic strategies for managing clinical scars.

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