Differentiation of Adipose-Derived Stem Cells by Stimulation with Extracellular Vesicles from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

September 2022 in “ Institutional Repositories DataBase (IRDB) ”

Taheruzzaman Kazi

adipose-derived stem cells extracellular vesicles dermal papilla cells osteogenic inducers adipogenic inducers FGF2 PDGF-AA hair-inductive genes microRNAs hair regeneration therapies alopecia stem cells EVs DPCs hair growth hair loss

TLDR Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.

The study investigated the differentiation of adipose-derived stem cells (ASCs) into dermal papilla cell (DPC)-like cells using extracellular vesicles (EVs) from DPCs activated with osteogenic and adipogenic inducers. The research demonstrated that the CAO1/2 medium, when supplemented with FGF2 and PDGF-AA, enhanced the expression of hair-inductive genes and maintained DPC-specific properties, leading to increased hair-forming activity. The study highlighted the role of specific microRNAs in regulating hair growth and suggested that DPC-EVs could effectively transform ASCs into cells with hair formation activity. This approach showed potential for hair regeneration therapies, offering a novel method for treating hair-related conditions like alopecia. However, the study acknowledged limitations in understanding miRNA expression and the characterization of DPC-EVs, indicating a need for further research.

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