Editorial: Advances And Novel Intervention In Photodermatology
April 2025
in “
Frontiers in Medicine
”
UV-induced skin damage photoaged skin single-cell RNA sequencing sebaceous gland cells keratinocytes melanocytes non-coding RNAs miR-4298 lncKRTAP5-6-3 skin repair mechanisms photoprotection inflammatory responses vitiligo CO2 laser therapy corticosteroids UV damage RNA sequencing skin cells skin repair skin inflammation laser therapy steroids
TLDR New insights into skin damage from UV exposure suggest potential treatments, including targeting specific RNAs and combining therapies for better outcomes.
This editorial highlights recent advances in understanding and treating UV-induced skin damage. Key findings include the identification of cellular changes in photoaged skin using single-cell RNA sequencing, revealing increased sebaceous gland cells, keratinocytes, and melanocytes in sun-exposed skin. The role of non-coding RNAs, specifically miR-4298 and lncKRTAP5-6-3, in regulating skin repair mechanisms was explored, suggesting potential therapeutic targets. Melanocytes were shown to provide photoprotection by reducing UV-induced damage and modulating inflammatory responses. A study on vitiligo treatment demonstrated that combining CO2 laser therapy with corticosteroids significantly improved outcomes, highlighting the benefits of addressing both structural and inflammatory aspects of skin conditions. These studies collectively advance the understanding of skin photodamage and suggest new therapeutic strategies.
