Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment

Hydrogel microneedle (HMN) systems represent a significant advancement in transdermal drug delivery, offering benefits such as biocompatibility, high drug-loading capacity, and tunable drug-release properties. These systems, made from natural and synthetic polymers, have potential applications in treating conditions like cancer, cardiovascular diseases, and hair loss. Notably, HMNs provide a minimally invasive and effective method for hair loss treatment, as demonstrated by systems developed for androgenetic alopecia that enhance therapeutic effects with lower doses. Despite their promise, challenges such as limited mechanical strength and lack of standardization remain. Future research should focus on material optimization and fabrication techniques to expand HMN applications in personalized medicine.