Recent Advances in Wound Healing, Tissue Repair, Regeneration, and Scar Management

February 2026 in “ Preprints.org ”

Nino Kuridze, Luiza Gabunia, Ketevan Ghambashidze, Sophio Giorgadze, Nodar Sulashvili, Christos Tsagkaris

wound healing tissue repair scar management molecular mechanisms cellular mechanisms biomaterials cell-based therapies gene therapies topical agents Dermatix Ultra Epicyn Flosteron Contractubex personalized medicine translational research Dermatix

TLDR New therapies and personalized approaches improve wound healing and patient quality of life.

The document discusses recent advances in wound healing, tissue repair, regeneration, and scar management, highlighting the complexity of these processes and the roles of various cells and signaling molecules. It emphasizes the impact of intrinsic factors like genetic predispositions, aging, and comorbidities on healing, as well as extrinsic factors such as infection and mechanical stress. Modern therapeutic strategies focus on optimizing the wound environment, preventing infections, and using advanced dressings and offloading devices. Stem cell therapy, innovative wound dressings, biomaterials, gene therapy, and RNA-based therapeutics show promise in enhancing tissue repair and regeneration. Advances in topical pharmacology have led to specialized formulations for different wound types, incorporating active ingredients to promote healing. The document underscores the importance of personalized approaches and novel therapies targeting chronic wounds to improve healing outcomes and patient quality of life.

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