Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-Inflammatory and Endocrine Dysfunction: A Narrative Review

This narrative review examines the intricate relationship between androgenetic alopecia (AGA) and polycystic ovary syndrome (PCOS), suggesting that AGA in PCOS results from a combination of systemic metabolic and hormonal dysregulation, including insulin resistance and chronic inflammation, rather than solely hyperandrogenism. It highlights the role of genetic predispositions and metabolic dysfunction in creating a vulnerable environment for hair follicles, where androgens amplify hair loss. The review emphasizes the need for a holistic, systems-level approach to treatment, addressing both cutaneous and systemic health outcomes, and calls for further research into precision-based care and regenerative therapies.