Biological Characteristics of Age-Related Changes in C57BL/6 Mice Sub-Strains in the National Center for Geriatrics and Gerontology Aging Farm

December 2024 in “ EXPERIMENTAL ANIMALS ”

Noboru Ogiso, Shunsuke YURI, Yoshiko Munesue, Akihiko Nishikimi, Atsushi Watanabe, Masashi Inui, Kazumichi TAKANO, Julio Almunia, Shumpei Niida

alopecia cutaneous infections renal lesions spontaneous tumors

TLDR B6J mice live longer before 24 months, but B6N mice live longer after; both strains show weight gain, increased food and water intake, and health issues as they age.

The study examined aging-related physiological and anatomical changes in two sub-strains of C57BL/6 mice, B6N and B6J. It found that B6J mice had a higher survival rate before 24 months but a lower rate afterward compared to B6N mice. Male mice gained weight until 15-18 months and females until 21-24 months, after which weight decreased. B6N mice had lower body temperatures until 24 months. Both strains showed increased food and water intake from 18 months. Female B6J mice had a higher incidence of alopecia from 3 months. Spontaneous tumors were common in both strains, with B6N mice showing more cutaneous infections and liver issues, while B6J mice, especially males, had more renal lesions. These findings enhance the understanding of aging in these mice, aiding geriatric research.

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