AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells

October 2024 in “ International Journal of Biological Sciences ”

YounHa Kim, Sang Bum Kim, Ho Lee, Doyeun Kim, Soon Sun Bak, Ina Yoon, Seongmin Cho, Seung Jae Jeong, Yoon Jeon, Jina Kim, Jihee Kim, Soohwan Oh, Khas-Erdene Battogtokh, Min‐Chul Park, Young Kwan Sung, Sung‐Hoon Kim

AIMP1 hair follicle stem cells dermal papilla cells TN41 Akt signaling pathway ERK signaling pathway β-catenin hair shaft elongation DPC spheroids

TLDR A peptide from hair follicle stem cells can boost hair growth.

This study found that a peptide fragment derived from AIMP1, secreted by hair follicle stem cells (HFSCs), promotes hair growth by activating dermal papilla cells (DPCs). The research showed that AIMP1 levels decrease with hair loss, and mice treated with AIMP1 experienced faster hair regrowth. The active region of AIMP1, identified as 41 amino acids (TN41), was shown to activate key signaling pathways (Akt and ERK), increase β-catenin, and enhance DPC activation. TN41 also promoted hair shaft elongation in cultured human hair follicles and improved the hair-inducing activity of cultured DPC spheroids, suggesting its potential in stimulating active hair regrowth.

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