Development of Alginate/Carboxymethylcellulose Films Incorporated with Canavalia Ensiformis Lectin (ConA) with Angiogenic Properties

    November 2025 in “ ACS Omega ”
    Maria H.C. Santos, Ana L.E. Santos, Israel J. M. Santos, Renato R. Roma, Abel V. M. Bisneto, Cléver Gomes Cardoso, B.A.M. Rocha, Lee Chen-Chen, Aryane Tofanello, Wanius García, Luís Cláudio Nascimento da Silva, Ariane M. S. Santos, Edson C. Silva-Filho, Claudener Souza Teixeira
    TLDR The films can help heal wounds by promoting blood vessel growth.
    This study explores the development of alginate/carboxymethylcellulose (CMC) films incorporated with Canavalia ensiformis lectin (ConA) to enhance wound healing through angiogenesis. The films demonstrated efficient incorporation of ConA, as confirmed by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR), which indicated that ConA is well-retained and anchored within the alginate matrix. The films showed increased expression of angiogenic factors TGF-β and VEGF, suggesting their potential to promote blood vessel growth and revascularization. These findings highlight the promise of these biopolymer films as effective wound treatment alternatives, warranting further research into therapeutic biofilms.
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