53 citations
,
February 2015 in “Journal of Investigative Dermatology” The study demonstrated that Ceramide Synthase 4 (CerS4) was crucial for regulating hair follicle stem cell homeostasis and hair follicle cycling in mice. Inactivation of CerS4 led to premature activation of hair follicle bulge stem cells, resulting in prolonged anagen-like states and eventual hair loss in aged mice. This was linked to decreased bone morphogenetic protein (BMP) signaling and increased Wnt signaling, causing changes in hair follicle and sebaceous gland morphology, including increased proliferation and reduced quiescent stem cells. The findings suggested that CerS4 was essential for maintaining normal hair follicle cycling and preventing hair loss by regulating signaling pathways in the epidermis.
437 citations
,
August 2014 in “Cell metabolism” Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.
67 citations
,
April 2014 in “Biochemical Journal” Ceramide synthase 4 deficiency in mice leads to hair loss due to altered sebum lipids.
50 citations
,
April 2014 in “Nature Communications” The research identified new skin traits in mice, some linked to human skin conditions.
91 citations
,
June 2011 in “The EMBO Journal” TCF/Lef1 activity is essential for proper skin cell development and renewal.
73 citations
,
May 2009 in “Proceedings of the National Academy of Sciences” Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.
503 citations
,
May 2009 in “Cell stem cell” Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.
