Eph39 Alopecia Areata: Targeted Review of Adverse Events Associated with Clinical Studies of Treatments
June 2023
in “
Value in Health
”
TLDR Alopecia areata treatments often cause headaches and infections, highlighting the need for safer options.
This targeted review analyzed adverse events (AEs) in clinical studies of alopecia areata (AA) treatments, including 16 studies on 4 topical and 12 systemic therapies. The most frequently reported AEs were headaches (213 cases), nasopharyngitis (189), upper respiratory tract infections (188), acne (151), and folliculitis (49). Systemic treatments were mainly associated with headaches, URTIs, and nasopharyngitis, while topical treatments were linked to headaches, nasopharyngitis, and pruritus. The findings emphasize the need for therapies with better safety profiles and the importance of large-scale, double-blind, placebo-controlled trials to confirm the efficacy and safety of AA treatments.
