Alopecia Areata Clinical Trial Enrollment and Retention Outcome Factors Among Underrepresented Ethnic and Racial Groups: A Cross-Sectional Study

    July 2023 in “ Journal of the American Academy of Dermatology ”
    Rachel Elsanadi, Ilhan Esse, Celine Phong, Alyssa Ashbaugh Ortega, Katerina Yale, Natasha Atanaskova Mesinkovska
    TLDR Clinical trials for alopecia areata need better inclusion and retention of patients of color.
    This study examined the enrollment and retention of alopecia areata (AA) clinical trial participants across different ethnic and racial groups at the University of California, Irvine. The study involved 115 subjects, with 45.2% White, 24.3% Hispanic, 16.5% Asian, 12.2% Black, and 1.7% Pacific Islanders. Significant differences were found in enrollment and retention rates among these groups. Asian patients had the highest enrollment (84.2%) and lowest screen failure rates (15.8%), while Black patients had the lowest enrollment (42.9%) and highest screen failure rates (57.1%). Black patients also had higher withdrawal and early termination rates. The study highlights the need for improved diagnosis and evaluation of hair loss conditions among patients of color and suggests that addressing these disparities could lead to more representative clinical trial results.
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