No Increased Risk of Alopecia in Ankylosing Spondylitis Patients: A Population-Based Cohort Study in Taiwan

July 2022 in “ International Journal of Rheumatic Diseases ”

Jason Peijer Hsieh, Yung‐Heng Lee, Bo‐Jyun Wun, Yu‐Hsun Wang, Hsi‐Kai Tsou, James Cheng‐Chung Wei

alopecia ankylosing spondylitis atopic dermatitis

TLDR People with ankylosing spondylitis in Taiwan don't have a higher chance of getting alopecia.

The population-based cohort study, which analyzed data from over 1,000,000 patients in the Taiwan Longitudinal Health Insurance Database, found no increased risk of alopecia in patients with ankylosing spondylitis (AS). The study included 3,640 AS patients and 14,560 non-AS controls. The results showed no significant increase in alopecia risk in AS patients (crude HR 1.16, P = 0.595; adjusted HR 1.16, P = 0.599), even in subgroup analysis of different age, sex, and phenotypes of alopecia. However, a significant positive correlation was found between atopic dermatitis and alopecia (adjusted HR 8.05, P = 0.039).

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , December 2018 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research Alopecia Universalis During Treatment with Leflunomide and Adalimumab: Case Report

16 citations , April 2014 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

A patient lost all their hair while on rheumatoid arthritis medication.

research Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata

106 citations , January 2013 in “Clinical and Developmental Immunology”

Alopecia areata is caused by immune system attacks on hair follicles, often triggered by viral infections.

research Alopecia Areata as Another Immune-Mediated Disease Developed in Patients Treated with Tumor Necrosis Factor-Alpha Blocker Agents

61 citations , June 2010 in “Journal of the European Academy of Dermatology and Venereology”

Anti-TNF-α therapy may increase the risk of developing alopecia areata, especially in those with a history of autoimmune disease.

research Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects

41 citations , January 2009 in “International Journal of Trichology”

58% of men aged 30-50 have hair loss, with severity increasing with age.

research Autoimmunity: Alopecia Areata

143 citations , January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata is an autoimmune disease causing hair loss, treatable with immune-modulating drugs, and linked to genetics.