High-Dose Alpha-Tocopherol as a Preventive of Doxorubicin-Induced Alopecia

October 1986 in “ PubMed ”

Pérez García Je, M Macchiavelli, B Leone, Alfonso E. Romero, Rabinovich Mg, D Goldar, Carlos Vallejo

alpha-tocopherol doxorubicin alopecia vitamin E

TLDR Alpha-tocopherol does not prevent hair loss from doxorubicin.

The study evaluated the effectiveness of high-dose alpha-tocopherol acetate in preventing doxorubicin-induced alopecia in 20 patients with various solid tumors. Despite the treatment, 90% of the patients experienced severe hair loss, and 10% had moderate hair loss. The trial concluded that alpha-tocopherol did not demonstrate any protective activity against hair loss caused by doxorubicin.

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