Androgen Receptor Blockade Induces the Phagocytosis of MRSA and Pseudomonas Aeruginosa by Monocyte-Derived Macrophages In Vitro

September 2025 in “ e-space (Manchester Metropolitan University) ”

Belboul, Amina, El Mohtadi, Mohamed, Fadel, Abdulmannan, Mcloughlin, Jessica, Mahmoud, Ayman M, O’Malley, Caitlin, Ashworth, Jason

androgen receptor androgen receptor blockade monocyte-derived macrophages

TLDR Blocking androgen receptors helps immune cells better fight certain bacteria.

The study explores how blocking androgen receptors affects the phagocytic activity of monocyte-derived macrophages against MRSA and Pseudomonas aeruginosa in vitro. Results indicate that androgen receptor blockade enhances macrophage phagocytosis of these bacteria, suggesting a potential therapeutic approach for infections by these pathogens. The research highlights the role of androgen receptors in modulating immune responses, but does not detail the number of samples or participants involved.

View this study on orcid.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community How true is the statement: dead follicles don't grow back?

in Research/Science 110 upvotes 11 months ago

Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 1 year ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community so what do you guys think of Cosmerna + Ru or pyri ?

in Research/Science 10 upvotes 2 years ago

Hair loss treatments Cosmerna, RU, and Pyri discussed. Cosmerna inhibits androgen receptors, but not 100%, so RU/Pyri can be used synergistically.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 3 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community What new hair-loss treatments actually look exciting right now (Oct 2025)

in Research/Science 173 upvotes 4 months ago

New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 17 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

Similar Research

5 / 1000+ results

research Androgens and Cardiovascular Disease

658 citations , June 2003 in “Endocrine reviews”

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

research Androgen Receptor Blockade Induces the Phagocytosis of MRSA and Pseudomonas Aeruginosa by Monocyte-Derived Macrophages In Vitro

September 2025 in “Deleted Journal”

Blocking androgen receptors boosts macrophages' ability to clear certain bacteria.

research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

research Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing

108 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

Lowering testosterone speeds up wound healing in male mice.

research Pathways to Inflammation: Acne Pathophysiology

68 citations , May 2011 in “European Journal of Dermatology”

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.