Androgenetik alopesi olan hastalarda nf kappa b, tnf-alfa, TGF-beta, tiyoredoksin, nitrik oksit, total oksidan status (TOS), total antioksidan status (TAS) düzeyleri ve tiyol disülfid homeostazisinin araştırılması

The study investigated the biochemical parameters associated with androgenetic alopecia (AGA), focusing on oxidative stress and its role in hair loss. Serum samples from patients with AGA and a control group were analyzed for levels of NF-κB, TNF-α, TGF-β1, thioredoxin, nitric oxide (NO), total oxidant status (TOS), total antioxidant status (TAS), and thiol-disulfide homeostasis. Results showed that individuals with AGA had significantly higher levels of NF-κB, TNF-α, TGF-β1, thioredoxin, NO, and TOS, while TAS, natural thiol, total thiol, and disulfide levels were significantly lower compared to the control group. The findings suggested that in AGA, the redox balance was disrupted, leading to increased oxidative stress and decreased antioxidant defense, contributing to microinflammation and perifollicular fibrosis, which accelerate hair loss. Understanding the effects of androgens on hair follicle cycles could aid in developing new treatments for AGA.