Angiogenic Capabilities Driven by Dermal Papilla Cells and Their Modulation by Androgen Action
November 2024
in “
Journal of Investigative Dermatology
”
dermal papilla cells androgens hair follicle cycling hair follicle stem cell differentiation VEGF vascular endothelial growth factor FGF fibroblast growth factor endothelial cell migration vascular network formation proangiogenic factors anagen phase hair growth cycle hair stem cells blood vessel growth blood vessel formation
TLDR Androgens reduce hair growth by affecting cell differentiation and blood vessel formation.
This study investigates the role of dermal papilla cells (DPCs) in hair follicle cycling and their modulation by androgens. It was found that androgens decrease DPC inductivity on hair follicle stem cell (HFSC) differentiation and negatively regulate the expression of angiogenic factors like VEGF and FGF in DPCs cultured as spheres. However, culturing DPCs as spheres promotes endothelial cell migration, vascular network formation, and proangiogenic factor expression. Although this increased angiogenic potential is lost when DPCs are cultured as a monolayer, it is restored when they are recultured as spheres. These findings suggest that androgens may impair the onset of the anagen phase by affecting HFSC differentiation and vascular network formation, with implications for translational medicine where large amounts of DPCs are required.
