The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model

    December 2024 in “ Bioengineering ”
    Qiong Deng, Shenzhen Pan, Fangzhou Du, Hongfei Sang, Zhi-xin Cai, Xiaoyu Xu, Qian Wei, Shuang Yu, Jingzhong Zhang, Chenglong Li
    TLDR Modified stem cell medium improves healing in diabetic wounds.
    The study explores the impact of conditioned medium from Angiopoietin-1 gene-modified mesenchymal stem cells (MSCAng1-CM) on wound healing in diabetic mice. It found that MSCAng1-CM significantly enhances wound healing by promoting angiogenesis, re-epithelialization, and hair follicle regeneration without causing excessive fibrosis. The treatment improved vascular maturation and stability, crucial for effective wound healing, and elevated collagen type I and III expression levels. These results suggest that MSCAng1-CM could be a promising cell-free therapy for diabetic wounds, offering a new approach to enhance existing treatment protocols.
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