Anti-Androgen Hormonal Therapy for Cancer and Other Diseases

    November 2019 in “ European Journal of Pharmacology
    Sebastian Student, Tomasz Hejmo, Aleksandra Poterała-Hejmo, Aleksandra Leśniak, Rafał Jakub Bułdak
    TLDR Anti-androgen therapy is crucial for treating cancer and hormone-related diseases, even with low testosterone levels.
    The document reviewed the role of anti-androgen therapies in treating cancer and other hormone-related diseases, highlighting the importance of androgen receptor signaling in these conditions. It discussed how anti-androgen drugs, which target the androgen receptor activated by 5α-dihydrotestosterone, are used both as primary and supportive treatments in multimodal therapeutic schemes. Despite the development of new anti-androgen agents, older hormonal drugs remained relevant in certain cases. The review emphasized that anti-androgen therapy was crucial even in diseases with low testosterone or DHT levels, offering a strategy to overcome resistance to primary treatments and improve therapeutic outcomes.
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