Antidiabetic, Hypolipidimic and Antioxidant Activities of Hibiscus Rosa Sinensis Flower Extract in Alloxan Induced Diabetes in Rabbits

The study evaluated the antidiabetic, hypolipidemic, and antioxidant activities of Hibiscus Rosa Sinensis flower extract in alloxan-induced diabetic rabbits. Conducted on 36 albino rabbits, the research compared the effects of the flower extract at doses of 50, 100, and 200 mg/kg with glibenclamide, a standard antidiabetic drug. The flower extract demonstrated a more gradual and sustained reduction in blood sugar levels over 72 hours compared to the rapid effect of glibenclamide. Additionally, the extract showed superior lipid-lowering and antioxidant effects. The findings suggested that the flower extract could be a safer and more effective alternative to traditional antidiabetic agents, potentially offering protection against cardiac complications like ischemic heart disease due to its antioxidant properties.