Antidiabetic Management Strategies for Treatment of Polycystic Ovarian Syndrome

February 2025 in “ Journal of Neonatal Surgery ”

Jaya Raju Nandikola, Sonali Wayal, S Vijayabanu, Ram Naresh, K S, Arindam Chatterjee, C. Jaganmohan, Mayuri Bhise, S. Devarakonda

polycystic ovarian syndrome insulin sensitizers metformin GLP-1 receptor agonists DPP-4 inhibitors oral contraceptives insulin resistance hyperandrogenism hormonal therapies PCOS birth control pills

TLDR Combining antidiabetic drugs, hormonal therapies, and lifestyle changes can improve health in women with PCOS.

This article discusses the management of polycystic ovarian syndrome (PCOS) using antidiabetic drugs, emphasizing the role of insulin sensitizers like metformin, GLP-1 receptor agonists, and DPP-4 inhibitors. These medications, when combined with hormonal therapies such as oral contraceptives, address both insulin resistance and hyperandrogenism. The article also underscores the importance of lifestyle interventions, including diet and exercise, as essential complements to pharmacotherapy. It calls for personalized treatment strategies and further research to enhance combination therapies for better long-term outcomes, highlighting a comprehensive approach to improving metabolic and reproductive health in women with PCOS.

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