Antimicrobial And Antibiofilm Activities Of Abietic Acid Against Skin-Associated Opportunistic Microorganisms

The study evaluated the antimicrobial and antibiofilm activities of abietic acid, derived from pine rosin, against skin-associated opportunistic microorganisms like Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Abietic acid showed significant antimicrobial effects with minimum inhibitory concentrations as low as 16 μg/ml and effectively reduced biofilm biomass in vitro, achieving over 90% reduction for P. aeruginosa and E. coli at higher concentrations. These findings suggest that abietic acid could be a promising candidate for further research into treatments for skin and soft tissue infections, particularly those complicated by biofilm formation and antibiotic resistance, although further research is needed to understand its mechanisms and clinical efficacy.