Lb1154 Rising Antimicrobial Resistance In Chronic Wounds

    July 2025 in “ Journal of Investigative Dermatology ”
    Catherine Delva, T. Gonzalez, E. Zhivov, J. Burgess, Hadar Lev‐Tov, M. Tomic-Canic, Irena Pastar
    TLDR DACC-based dressings are more effective than silver-based ones for treating chronic wounds with antimicrobial resistance.
    The study highlights the growing issue of antimicrobial resistance (AMR) in chronic wounds, particularly in patients with chronic venous leg ulcers. Among 24 patients, methicillin resistance was found in 66.67%, and mupirocin resistance in 83.33%. A randomized controlled trial compared the efficacy of silver-based dressings with Dialkylcarbomoyl chloride (DACC)-based dressings over 4 weeks. The DACC group showed better outcomes, with lower bacterial loads and higher healing rates, while the silver group had higher bacterial loads and persistent inflammation. The study emphasizes the need for antimicrobial stewardship and novel treatment strategies to combat AMR in chronic wounds.
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