The Significance Of The Apelinergic System In Doxorubicin-Induced Cardiotoxicity

    July 2024 in “ Heart Failure Reviews ”
    Katarzyna Matusik, Katarzyna Kamińska, Aleksandra Sobiborowicz, Hubert Borzuta, Kasper Buczma, Agnieszka Cudnoch‐Jędrzejewska
    TLDR The apelinergic system might protect the heart from damage caused by doxorubicin.
    This review discusses the potential protective role of the apelinergic system in mitigating doxorubicin (DOX)-induced cardiotoxicity, a common side effect of cancer treatment. Doxorubicin therapy can lead to decreased left ventricle echocardiography parameters, increased oxidative stress, and cardiac fibrosis. The apelinergic system, involving apelin and its receptor, may offer therapeutic benefits by protecting the heart from these damages. However, further research in chronic preclinical models is necessary to confirm these benefits and elucidate the underlying mechanisms.
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