Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

    March 2001 in “ Journal of Investigative Dermatology ”
    Justine A. Ellis, Margaret Susanne Stebbing, Stephen Harrap
    TLDR Male pattern baldness is linked to specific genetic variations in the androgen receptor gene.
    The study found a significant association between male pattern baldness (MPB) and polymorphisms in the androgen receptor (AR) gene. Researchers observed that the StuI restriction site was present in 98.1% of young bald men and 92.3% of older bald men, compared to 76.6% of non-bald men, indicating a strong genetic link. Additionally, shorter CAG and GGC triplet repeats were more common in bald men. These findings suggested that these genetic markers were closely linked to a functional variant necessary for the polygenic determination of MPB, highlighting the complexity of MPB involving both genetic predispositions and androgen receptor activity.
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      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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