Autosomal Recessive Woolly Hair Caused by LIPH Mutations: A Case Series of Six Chinese Patients

November 2025 in “ Clinical Cosmetic and Investigational Dermatology ”

Can Cui, Xi Chen, Yingzi Zhang, Jianyi Ni, Jin-Yuan Ma, Aihua Wei

autosomal recessive woolly hair LIPH mutations c.454G>A p.G152R

TLDR LIPH mutations cause woolly hair in some Chinese people.

This study investigates autosomal recessive woolly hair (ARWH) caused by LIPH mutations in six Chinese patients, highlighting the c.454G>A (p.G152R) variant as a potentially recurrent allele in this population. The findings contribute to a broader understanding of LIPH-related ARWH among Chinese individuals.

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