Engineering a Skin-Mimicking Asymmetric Poly(L-Lactic Acid)/Gelatin Bioscaffold for Skin Repair

The study successfully engineered an asymmetric poly(L-lactic acid)/gelatin bioscaffold for skin repair, demonstrating its potential for epidermal–dermal regeneration. The scaffold was fabricated using electrospinning techniques and stabilized with genipin cross-linking, resulting in a structure with continuous core–shell fibers and an interconnected nanofibrous network. The scaffold exhibited skin-relevant mechanical properties and controlled hydration, with differential wettability between its components. In vitro tests showed that NIH 3T3 fibroblasts proliferated well and achieved approximately 95% scratch closure within 48 hours on the scaffold. These findings suggest that the genipin-stabilized scaffold is a promising candidate for skin repair applications, with potential for integrated sensing or drug delivery.