Autologous Platelet Concentrates for the Treatment of Primary Cicatricial Alopecia: A Systematic Review

This systematic review evaluated the use of autologous platelet concentrates (APCs) for treating primary cicatricial alopecia (PCA), involving 14 studies with 50 patients, 38 of whom were treated with APCs. The review found that APCs, particularly when combined with topical clobetasol, may reduce disease activity, control hair loss progression, and improve hair density, with 92.3% of cases reporting hair density improvement. However, the durability of these improvements post-treatment was limited. APCs were generally well tolerated, with only mild transient injection-site pain reported. Despite these promising results, the evidence is limited by small sample sizes and study heterogeneity, highlighting the need for high-quality randomized controlled trials with standardized protocols and long-term follow-up.