Autologous skin transplantation using water extract of bay leaves (Laurus nobilis L.)

This study investigated the effects of aqueous bay leaf extract on skin graft healing in 16 rabbits. The rabbits were divided into two groups: a control group and a treatment group receiving bay leaf extract. Skin biopsies were taken on days 3, 7, 14, and 21 post-surgery. The treatment group showed reduced inflammation and edema by day 3, improved collagen organization and hair follicle dilatation by day 7, and extensive dermal fibrosis by day 14. By day 21, the treated wounds exhibited more mature fibrosis and glandular proliferation compared to the control group. The findings suggest that bay leaf extract can significantly accelerate skin graft healing by modulating inflammation and enhancing tissue regeneration, indicating its potential as a natural therapeutic agent for wound treatment.