Autophagy Protects Murine Preputial Glands Against Premature Aging and Controls Their Sebum Phospholipid and Pheromone Profile

September 2021 in “ Autophagy ”

Heidemarie Rossiter, Dragan Copic, Martin Direder, Флориан Грубер, Samuele Zoratto, Martina Marchetti‐Deschmann, Christopher Kremslehner, Michaela Sochorová, Ionela‐Mariana Nagelreiter, Veronika Mlitz, Maria Buchberger, Barbara Lengauer, Bahar Golabi, Supawadee Sukseree, Michael Mildner, Leopold Eckhart, Erwin Tschachler

autophagy ATG7-dependent macroautophagy preputial glands lipid profiles pheromone production single-cell RNA sequencing lipid metabolism oxidative stress phospholipid levels diacyl glycerides mass spectrometric imaging phosphatidylcholine sebocytes palmityl acetate

TLDR Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.

The study demonstrated that autophagy, particularly ATG7-dependent macroautophagy, was crucial for maintaining the health and function of murine preputial glands. Inactivation of autophagy led to premature aging, ductal ectasia, and altered lipid droplet morphology. Single-cell RNA sequencing revealed downregulation of genes involved in lipid metabolism and oxidative stress response in ATG7-deficient glands. Lipid analysis showed decreased levels of most phospholipid classes and an accumulation of diacylglycerides, along with a significant reduction in the pheromone palmityl acetate. These findings highlighted the essential role of autophagy in gland homeostasis, lipid metabolism, and pheromone production.

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